Within this structure and this drush command, it is now possible to do that via drush.
Now drush can update Drupal.
Here is the very specific structure this command deals with for multi-drupalupdate and multi-create :
' drupal/ |-- 6.x -> drupal-6.14 |-- 6.x_backup |-- 6.x_profiles |-- 6.x_sites | |-- all | |-- default | |-- example.com | | |-- files | | |-- modules | | `-- themes | `-- sub.example.com | |-- files | |-- modules | `-- themes `-- drupal-6.14 |-- backup -> ../6.x_backup |-- includes |-- misc |-- modules |-- profiles -> ../6.x_profiles |-- scripts `-- sites -> ../6.x_sites '